Coach Chan Gailey had no details on the injury but said it "doesn't look good at all."
Miami cornerback Sean Smith hurt his left knee in the second half. He walked off the field, but did not return.
Bills fullback Dorin Dickerson was carted off the field late in the fourth quarter with a right ankle injury. Safety Da'Norris Searcy hurt his groin in the second quarter, and cornerback Stephon Gilmore left with a head injury in the third quarter.
Chandler ranks second on the Bills in receptions with 43 and has scored six touchdowns.
"You lose a good amount with Scott not in there in terms of his feel for the game and the way that we kind of have a good connection," Gailey said.
The Dolphins won 24-10.
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