| |
| Rk | PASSING YDS | PYd |
| 1 | Matthew Stafford, DET | 422 |
| 2 | Ben Roethlisberger, PIT | 398 |
| 3 | Eli Manning, NYG | 384 |
| 4 | Aaron Rodgers, GNB | 344 |
| 5 | Tom Brady, NWE | 310 |
| Rk | RUSH YDS | RuYd |
| 1 | Chris Johnson, TEN | 151 |
| 2 | Ryan Grant, GNB | 129 |
| 3 | DeAngelo Williams, CAR | 122 |
| 4 | Bernard Scott, CIN | 119 |
| Ricky Williams, MIA | 119 |
| Rk | REC YDS | RcYd |
| 1 | Terrell Owens, BUF | 197 |
| 2 | Wes Welker, NWE | 192 |
| 3 | Calvin Johnson, DET | 161 |
| 4 | Derrick Mason, BAL | 142 |
| 5 | Hines Ward, PIT | 128 |
| Rk | PASSING TD | PTD |
| 1 | Matthew Stafford, DET | 5 |
| 2 | Brett Favre, MIN | 4 |
| Brady Quinn, CLE | 4 | |
| 4 | Eli Manning, NYG | 3 |
| Drew Brees, NOR | 3 | |
| 2 others tied | 3 |
| Rk | RUSH TD | RuTD |
| 1 | Carson Palmer, CIN | 2 |
| Laurence Maroney, NWE | 2 | |
| Jason Snelling, ATL | 2 | |
| Mike Bell, NOR | 2 | |
| Ricky Williams, MIA | 2 |
| Rk | REC TD | RcTD |
| 1 | Sidney Rice, MIN | 2 |
| Kevin Boss, NYG | 2 | |
| Robert Meachem, NOR | 2 | |
| 4 | Leonard Pope, KAN | 1 |
| Rashard Mendenhall, PIT | 1 | |
| 44 others tied | 1 |
| Rk | TACKLES | Tack |
| 1 | James Laurinaitis, STL | 16 |
| 2 | David Hawthorne, SEA | 15 |
| 3 | David Harris, NYJ | 14 |
| 4 | Michael Boley, NYG | 13 |
| London Fletcher, WAS | 13 |