College coaches are looking for ways to either avoid or exploit these matchups, and NFL talent evaluators can't wait to watch future pros go head-to-head on the biggest stages.
So no matter what lens you're looking through, these are some of the premier matchups in many of the top college football games this Saturday.
Note: Underclassmen are marked with an asterisk.
WR Laquon Treadwell vs. CB Vernon Hargreaves III
Ole Miss Rebels at Florida Gators (7 p.m. ET, ESPN)
Treadwell has recovered nicely from a gruesome leg injury last season, averaging 83 receiving yards per game to start the 2015 campaign. He's one of the top wide receivers in the 2016 draft class due to his elite length and timing. He'll have the height advantage against Hargreaves -- 6-foot-2 vs. 5-foot-11 -- but the Florida cornerback has the skills to stick with him step-for-step. My No. 3 overall player, Hargreaves already has two interceptions on the season. This battle could come down to whether Hargreaves can throw off Treadwell's timing by playing bump-and-run at the line.