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Power Rankings: No. 12 San Francisco 49ers

A weekly examination of the 49ers’ ESPN.com Power Rankings:

Rank: 12| Last Week: 7

Comment: The 49ers’ (4-3) three-game winning streak came to a crashing halt Sunday night in Denver during a 42-17 loss to the Broncos in Peyton Manning’s record-setting game.

That defeat sent the Niners tumbling five spots in our Power Rankings.

Truly, the bye week could not have come at a better time for a team so nicked up physically -- and mentally. Against the Broncos, the 49ers were without five players projected to be starters -- left guard Mike Iupati (concussion), linebackers Aldon Smith (suspension), NaVorro Bowman (knee) and Patrick Willis (toe) and cornerback Chris Culliver (hamstring).

And that was before losing center Daniel Kilgore in the game to a season-ending broken left ankle.

The time off figures to help with the healing process, and there are reports that Smith’s nine-game suspension, which lasts through the 49ers’ Nov. 9 game at the New Orleans Saints, could be reduced for good behavior by a game or two, which would conceivably bring him back for their first post-bye game at home against the St. Louis Rams on Nov. 2.

Plus, running back Marcus Lattimore is scheduled to begin practicing soon as his rehab from his college knee injury ramps up. And the return of nose tackle Glenn Dorsey (left biceps) is also on the horizon.