A weekly look at what the Chargers must fix.

The San Diego Chargers travel to Buffalo on Sunday for a Week 3 contest against the 2-0 Buffalo Bills. San Diego offensive coordinator Frank Reich will have to devise some plays to create space for his running backs. And he’ll have to manufacture those runs against a pretty good Buffalo defensive front that’s holding teams to an average of 83 rushing yards per contest, No. 6 in the NFL.

The Chargers ran the ball 37 times for 101 yards. Last season, the Chargers finished 10-1 when they ran the ball at least 27 times. Throughout his career as a coach and offensive coordinator, teams led by Chargers coach Mike McCoy have finished 36-14 in games they have run the ball at least 27 times.

Still, through two games the Chargers are averaging just 2.5 yards per carry, which is tied with Jacksonville for the worst in the NFL. And bringing that number up will be made harder by the fact that every-down running back Ryan Mathews will be out four to five weeks with an MCL sprain in his right knee injury. At 3.1 yards per carry, Mathews leads San Diego’s stable of running backs.