A few thoughts on the Pittsburgh Steelers’ 43-19 loss to the Buffalo Bills:

What it means: This was an unsettling performance from a defense that needs to be cleaned up, and fast. Can the Steelers stop anybody? Several Steelers looked out of position on two long Bills gains in the first quarter. When Bills quarterbacks – yes, the Bills – complete 23 of their first 25 passes for 304 yards, you know it’s a brutal day.

Play of the game: In his first play as a Steeler, Michael Vick threw a 63-yard deep ball to Martavis Bryant down the sideline. Bryant skied over the cornerback to make the play. Welcome to Pittsburgh, Michael.

Stat of note: The Steelers have gone for four two-point conversions this preseason, including two in the first half Saturday. Expect Pittsburgh to take the occasional two-point chance after touchdowns during the regular season.

Injuries of note: Kicker Garrett Hartley left the game with a hamstring injury, leaving second-string punter Jordan Berry on kickoffs. The Steelers signed Hartley to replace Shaun Suisham, who tore his anterior cruciate ligament three weeks ago. Outside linebacker Bud Dupree left the game with a right foot injury. The severity is unknown.

What’s next: The Steelers finish the preseason with a Thursday home game at 7:30 p.m. ET against the Panthers. Because the Bills challenged the Steelers' secondary, Cam Newton should, too.