SANTA CLARA, Calif. -- The Washington Redskins will be without four starters for Sunday's game versus San Francisco, with one unexpected player being deactivated.

Left tackle Trent Williams, tight end Jordan Reed, corner David Amerson and nose tackle Chris Baker all were declared inactive. Amerson was the unexpected one; he was not on the injury report during the week.

With Williams out, rookie Morgan Moses will make his first start after playing the final three quarters last week against Tampa Bay. Here's a story on Moses from earlier in the week regarding his performance. He'll face elite pass-rushing linebacker Aldon Smith on Sunday, which is a tougher task, but the Redskins probably won't leave him one-on-one too often.

Niles Paul will take over the role as pass-catching tight end; the Redskins felt the Niners were vulnerable in coverage against tight ends. Stephen Bowen will be active with Baker sidelined. The Redskins could end up with Barry Cofield at nose and Bowen and Jason Hatcher at end. Bowen was inactive last week. Tracy Porter will start for Amerson.

The other inactives: quarterback Kirk Cousins, receiver Aldrick Robinson and receiver Leonard Hankerson.