The night belonged to Denver Broncos quarterback Peyton Manning, who established a record for most touchdown passes in a career in Denver’s 42-17 rout of the San Francisco 49ers Sunday night.

But where did the game truly get away from the Niners, whose 42 points allowed are tied for their most under fourth-year coach Jim Harbaugh?

Look no further than their offensive line, which was more makeshift line than front line by the time the game ended.

Consider that the 49ers were already without left guard Mike Iupati, who suffered a concussion six days earlier, and Anthony Davis was making just his second start of the season at right tackle thanks to injury.

The Niners then lost center Daniel Kilgore to a potentially season-ending broken left ankle/leg and his backup, undrafted rookie Dillon Farrell, rolled an ankle.

Colin Kaepernick was sacked a season-high six times and the resultant grades for offensive linemen were ugly.

Per Pro Football Focus, left tackle Joe Staley allowed three sacks and Joe Looney, who started at left guard in place of Iupati, surrendered six quarterback pressures and had a minus-5.7 grade.

Davis, who dealt with Von Miller, had an overall grade of minus-3.8 while right guard Alex Boone had his first positive grade as a starter this season at plus-3.8.

And when you look at how the 49ers attempted to attack the Broncos, PFF says they did not attempt one rushing play outside of Davis at right tackle while only using two-tight end personnel on 13.3 percent (10 of 75) of their plays, the same percentage as when they had two running backs on the field.

The bye week comes at a perfect time for the heart of the Niners’ offense -- the O-line -- to try and get right … and healthy.