EDEN PRAIRIE, Minn. -- The Minnesota Vikings will be without three defensive starters and an offensive lineman on Sunday in Detroit, and Cordarrelle Patterson's status is uncertain.

The Vikings listed linebacker Anthony Barr (knee), safety Robert Blanton (ankle/knee), defensive tackle Sharrif Floyd (knee) and guard Charlie Johnson (ankle) as out for Sunday's game against the Lions. Patterson, who showed up on the injury report for the first time on Friday, is listed as questionable with a hamstring injury.

Patterson was returning kickoffs during the open portion of practice, which means he could have tweaked his hamstring later in the session once it was closed to reporters. He played only one offensive snap last week against the New York Jets and lost a fumble on the opening kickoff in the second half.

The loss of Barr and Floyd, in particular, might hinder the Vikings as they face the 9-4 Lions on Sunday afternoon. Detroit's offense thrives when Matthew Stafford has time to throw downfield to Calvin Johnson, and though the Lions beat the Vikings with quick passes in Week 6, Johnson wasn't on the field for that game. Stafford has been sacked 39 times this year; the Vikings can hope for another big day from Everson Griffen, but having Barr and Floyd would certainly help them generate a pass rush.

With Blanton out, Andrew Sendejo figures to start at safety next to Harrison Smith. Vlad Ducasse will likely start at left guard with Johnson sidelined, meaning the Vikings will have just two of their five preferred linemen (Matt Kalil and John Sullivan) on the field against a Lions pass rush that took Teddy Bridgewater down eight times on Oct. 12.