SAN DIEGO -- At least they weren’t no-hit!

The Mets, who stormed into the All-Star break by winning eight of 10 games on their homestand, got tripped up in San Diego to open the second half. In his fifth major league start, eephus-throwing Cuban defector Odrisamer Despaigne held the Mets hitless until Daniel Murphy's two-out double in the eighth and the Padres ultimately won, 2-1, in Sunday’s rubber game at Petco Park.

David Wright followed Murphy’s double with a game-tying RBI single on Despaigne’s 123rd and final pitch, snapping an 0-for-11 drought to begin the second half.

However, Seth Smith produced a walk-off win for San Diego with a two-out run-scoring infield single against Josh Edgin in the bottom of the ninth. Edgin stumbled trying to field the trickler and could not get the ball to first base in time.

Edgin had inherited the winning run on third base with two outs from Vic Black, who hurt himself. Black had issued a leadoff walk to Carlos Quentin, then had a fielding error on Alexi Amarista's sac-bunt attempt to place two on with none out.

The Mets (46-52), who fancy themselves part of the NL East race, fell eight games back of the victorious Washington Nationals and Atlanta Braves.

Odrisamer Despaigne held the Mets hitless until Daniel Murphy's two-out double in the eighth.

The Padres, who have played 7,264 games in franchise history, remain the only MLB team without a no-hitter. They had a chance to win the game in the eighth after a leadoff triple by Will Venable against Jeurys Familia, but Chris Denorfia struck out and Chris Nelson followed an intentional walk by grounding into an inning-ending double play.

The Mets last were no-hit by Houston’s Darryl Kile in 1993. They have been no-hit six times in franchise history. The other pitchers to accomplish the feat against the Amazin’s: Sandy Koufax (1962), Jim Bunning (1964), Bob Moose (1969), Bill Stoneman (1972) and Ed Halicki (1975).

The Mets had loaded the bases on a hit batter and two walks in the seventh, but Ruben Tejada hit a comebacker to Despaigne as the right-hander wriggled free.

Zack Wheeler departed after Tejada’s groundout with the Mets trailing 1-0. Wheeler has now completed six innings and allowed one run in four straight starts. He has sliced his ERA to 3.78.

Yasmani Grandal reached for a low-and-away pitch and hooked it over the right-center wall to lead off the bottom of the fourth against Wheeler for the lone damage against him. It was Grandal’s second straight game with a solo shot to open the scoring.

The Mets also were held hitless two outs into the eighth inning on April 18 against the Braves. After seven no-hit innings by Aaron Harang, Wright produced a two-out single in the eighth against reliever Luis Avilan that day for the lone hit in a 6-0 loss at Citi Field.

The Mets had been held hitless into the fifth inning Saturday against Tyson Ross.

Despaigne had allowed four runs on five hits and five walks in four innings against Las Vegas in his Triple-A debut on May 27.

What’s next: The Mets visit Seattle for the first time since 2005. Jonathon Niese (5-4, 2.96 ERA) returns from the disabled list to start the series opener opposite left-hander Roenis Elias (7-8, 4.54) at 10:10 pm. ET.

Monday marks the 10-year anniversary of Wright’s July 21, 2004 major league debut -- an 0-for-4 performance against the Montreal Expos at Shea Stadium.