JACKSONVILLE, Fla. -- Since beating Indianapolis 22-17 in Week 3 of the 2012 season, the Jaguars haven’t even come close to being competitive with the Colts. They’ve lost the last four meetings by a combined 98 points (24.5 per game) and have scored just 40 points in those games. The Colts scored 44 in a 27-point rout of the Jaguars earlier this season.

The reason the Colts won that day is the same reason they won the previous three meetings: Andrew Luck. He torched the Jaguars for 370 yards and four touchdowns, completing 31-of-39 passes. In the four games since the Jaguars won in their first matchup with Luck in 2012, the former Stanford standout has completed 7.01 percent of his passes for 1,136 yards and seven touchdowns with two interceptions against the Jaguars.

Jacksonville will be breaking in another rookie in the secondary: nickelback Aaron Colvin, who will make his pro debut after rehabbing a torn ACL. Plus, the Jaguars will be without their best defender (linebacker Paul Posluszny) and pass rusher (Andre Branch). Unless Blake Bortles is up for a shootout -- which seems unlikely, as the Jaguars lost leading receiver Allen Robinson for the season with a stress fracture in his foot -- the Jaguars are going to have another long day.

My prediction: Indianapolis 35, Jacksonville 17