ORCHARD PARK, N.Y. -- The Buffalo Bills (2-0) will look to retain sole possession of first place in the AFC East when they host the San Diego Chargers (1-1) on Sunday.

Here is what to watch for:

1. Robert Woods' status: After coach Doug Marrone said Thursday that wide receiver Robert Woods wouldn't be able to play "right now," Woods' ankle apparently improved enough that he was able to practice Friday and is listed as probable for Sunday's game. On Thursday, fellow wideout Sammy Watkins said he hopes for him and Woods to become a top receiver duo in the mold of Julio Jones and Roddy White. That's telling, as Woods' role was in doubt less than a month ago. He's now clearly ahead of Mike Williams in the offense's hierarchy. Still, Williams may have a chance to change that if Woods' reps are limited Sunday because of his ankle injury.

2. Favorable matchups for Bills: There are a few statistical areas where the Bills could receive a break Sunday. The first is red zone offense, where the Bills rank 29th through two weeks but the Chargers have allowed touchdowns on four of five opponent trips this season. The second area is run defense. The Bills' defense has allowed 4.26 yards per carry, 15th-best in the NFL. However, the Chargers average a league-worst 2.51 yards per carry and will be without Ryan Mathews. If the Bills can have success in each of those phases, they'll be in good shape Sunday.

3. Chess match between Bills' defense, Chargers' offense: Meanwhile, there are some matchups that the Chargers can exploit. The Bills lost some athleticism at linebacker when Kiko Alonso suffered a season-ending injury and they could also be without Keith Rivers (doubtful, groin). Nigel Bradham and Preston Brown will be a likely combo at linebacker on passing downs. Expect the Chargers to send tight ends Antonio Gates and Ladarius Green over the middle and up the seam, challenging the Bills' linebackers. The Bills could counter by bringing a safety closer to the line of scrimmage, so keep an eye on Da'Norris Searcy and his alignment. If he creeps down into the box, the Chargers could turn to the outside and test the Bills' cornerbacks with wide receiver Keenan Allen.

4. Watching the weather: There is currently a 40 percent chance of thunderstorms Sunday. If heavy rain happens to move into the area during the game, I'd expect the Bills to have the advantage. They have a stronger running game than the Chargers and rely less on passing than any other team in the NFL.