INDIANAPOLIS – Indianapolis Colts starting linebacker Jerrell Freeman will miss his second straight game with a hamstring injury.

Center Khaled Holmes, who has been out since Aug. 7 with a high ankle sprain, is healthy enough to play, but coach Chuck Pagano said A.Q. Shipley will start against Jacksonville on Sunday. Pagano didn’t even guarantee Holmes will be on the active roster against the Jaguars. Shipley has played well in the two games he has started in place of Holmes.

“Like anybody else coming off an injury, whatever it is, I’m not going to just throw a kid to the wolves if he’s not 100 percent and ready to play,” Pagano said about Holmes. “Mentally it’s not an issue. He’s knows exactly what to do, but physically he hasn’t played for a while. We’re going make sure that ankle is 100 percent before we throw him back out there.”

Here’s the rest of the Colts’ injury list for Sunday’s game:

Out: Freeman, DL Arthur Jones (ankle)

Questionable: DL Ricky Jean Francois (ankle), WR Hakeem Nicks (illness), OL Joe Reitz (ankle)

Probable: CB Darius Butler, WR T.Y. Hilton, CB Greg Toler, Holmes