Everybody is on Upset Alert this week!

Thursday night

No. 2 Florida State (7-0, 4-0) at Louisville (6-2, 4-2), 7:30 p.m., ESPN. Line: Florida State by 3.5. Many believe this is the toughest game remaining on the schedule for the Noles. There are several reasons for that. Louisville brings the No. 1 defense in the nation to the game, a group that is holding opponents to 14.6 points per game. Not only have the Cards kept scoring down, they rank No. 1 in the nation in rushing defense, No. 2 in interceptions (15), No. 7 in sacks (29). Safe to say Louisville will be coming after Jameis Winston early and often. But do the Cards have enough offense with receiver DeVante Parker back in the mix to pull the upset?

Saturday

No. 24 Duke (6-1, 2-1) at Pitt (4-4, 2-2), noon, ESPNU. Line: Pitt by 3.5. These two teams played a wild game a season ago, with the Panthers prevailing 58-55. Duke comes into this one off a bye, while Pitt has to shake off a miserable game against Georgia Tech in which it turned the ball over on its first five possessions. Duke has been the better team this season, so it is a little surprising to see Pitt favored, especially off such a bad performance.

Boston College (5-3, 2-2) at Virginia Tech (4-4, 1-3), 12:30 p.m, ESPN3. Line: Virginia Tech by 3. Easy to envision a BC win in this one when you look at one key factor: Virginia Tech has been unable to stop running quarterbacks this season. Couple that with a terrible performance last week against Miami, and maybe the Eagles win again. Tyler Murphy has failed to run for 100 yards just once this season -- against USC.

North Carolina (4-4, 2-2) at Miami (5-3, 2-2), 12:30 p.m., ESPN3. Line: Miami by 17. The line in this game seems a bit high considering the Tar Heels are on a bit of a roll after two straight wins. There is no doubt Miami presents many more challenges to a struggling UNC defense -- both from Duke Johnson and its speedy receivers. But the North Carolina offense presents more challenges than Virginia Tech did. Marquise Williams and Mack Hollins are playing at a high level and will force Miami to have a different defensive plan this weekend.

NC State (4-4, 0-4) at Syracuse (3-5, 1-3), 3 p.m., ESPN3. Line: Syracuse by 3.5. The Wolfpack go into this game off a much-needed bye week, while Syracuse could be emotionally spent after losing a close game to Clemson last week. Both need this game to help their bowl hopes. While the Syracuse defense has looked impressive the last two weeks, Jacoby Brissett presents a tougher matchup than Wake Forest and Clemson did. If Syracuse cannot get its offense going, NC State could get its first ACC victory since 2012.

Virginia (4-4, 2-2) at Georgia Tech (6-2, 3-2), 3:30 p.m. ESPNU. Line: Georgia Tech by 3.5. This is another must-win Coastal game for both teams, trying to keep pace with Duke atop the standings. Virginia has now dropped two straight after its impressive start to the season and it does not get any easier from here. But its defense will have a chance to slow down the run game because it has one of the stronger front sevens in the league. If the Hoos can get back to forcing turnovers the way they did in their first six games, their victory chances improve greatly.