The best day of the week is finally here. Is the best league game of the year here as well? Probably. Here's a primer on all of the action throughout the day. Be sure to follow along on Twitter with all of the hashtags below.
Noon
Georgia Tech at Virginia Tech, ESPN, #GTvsVT: The Yellow Jackets have gotten to 3-0 in the most wayward of fashions. The Hokies are coming off a home loss to East Carolina, one week after upsetting a top-10 Ohio State team on the road. Could their trouble be on defense? Brandon Facyson has been playing hurt all season, sure, but Virginia Tech has surrendered 22 plays of 20 yards or more this season, fourth-most in the nation and half its total from last season (44). The big-play threat might not exactly be there with Georgia Tech, but as Jared Shanker noted this week, the visitors do bring with them a knack for converting third downs. Virginia Tech has won the past four games in this matchup.
Iowa at Pittsburgh, ESPNU, #IOWAvsPITT: Third-year Panthers coach Paul Chryst hosts a familiar foe this weekend, as he faced the Hawkeyes six times while he was offensive coordinator at Wisconsin, going 3-3. Pitt is looking for its first 4-0 start since 2000, and it will likely turn to the nation's leading rusher, James Conner, to try to get there, despite Iowa's stingy run defense (No. 7 nationally). Iowa coach Kirk Ferentz, by the way, will experience a homecoming of sorts, as he went to Upper St. Clair High in Pittsburgh.
12:30 p.m.
Maryland at Syracuse, 12:30, ESPN3, #MDvsCUSE: The Terrapins are in their first year away from the "basketball" conference that is the ACC, as coach Randy Edsall said this summer, and the Big Ten newcomers will look to avenge last year's 20-3 home loss to the Orange, which came without receivers Stefon Diggs and Deon Long. Syracuse, meanwhile, looked like a new team in last week's 40-3 win at Central Michigan, as it came off a bye and had quarterback Terrel Hunt back running the show on offense. Syracuse is looking to get to 3-0 for the first time since 1991, which would provide a big boost to a team that will embark on a difficult three-week stretch against Notre Dame, Louisville and Florida State.
Tulane at Duke, ESPN3, #TULNvsDUKE: Has there been a more overlooked team than Duke recently? All the Blue Devils have done is take care of business, coming off a 10-win, division-title season and starting 3-0 this season in methodical fashion (albeit against bad competition). In any event, the unranked Blue Devils close their nonconference slate against American Athletic Conference newcomer Tulane, which is no stranger to the ACC this season, having lost to Georgia Tech two weeks ago. Here's one interesting stat surrounding Duke quarterback Anthony Boone, courtesy of ESPN Stats & Information: The Blue Devils have lost yardage on just three percent of Boone's snaps, the lowest percentage of any Power Five quarterback with at least 150 plays.
1 p.m.
Maine at Boston College, ESPN3, #MEvsBC: It's all about avoiding a letdown this week in Chestnut Hill, where the Eagles produced one of the young season's greatest upsets last weekend against USC. The Black Bears should hardly pose a huge challenge to BC, which, with Tyler Murphy under center, has been able to stretch the field much more than last season, even if the run game is still its bread and butter. Murphy leads all quarterbacks in rushing yards this season with 401, 40 more yards than he has tallied passing the ball (361).
3:30 p.m.
Louisville at FIU, Fox Sports 1: The Cardinals are looking to rebound from their first defeat of the second Bobby Petrino era, while the Golden Panthers welcome their second straight ACC foe to Miami. FIU gave Pitt a handful last week before the Panthers pulled away, but Louisville will probably not be so kind coming off the loss at Virginia. Louisville beat FIU 72-0 a year ago, and while there are plenty of new faces, quarterback Will Gardner will try to bounce back after getting pulled a week ago. His offensive line will look to get its act together as well.
Virginia at No. 21 BYU, ESPN, #UVAvsBYU: Speaking of the Cavaliers, they should serve as one of the toughest tests the Cougars face all season, as the home team has the best chance of anyone in the nation at running the regular-season table (21.7 percent, per ESPN's FPI). We'll see just how good this Virginia defense really is after strong showings through the first three weeks, as BYU quarterback Taysom Hill and his home field will be a handful to handle. Virginia beat BYU last year in the season opener, one of just two games it won all season.
Army at Wake Forest, ESPN3, #ARMYvsWAKE: The Demon Deacons' defense has actually been pretty good through three games despite a 1-2 record. And while the offense showed signs of life late in last week's loss at Utah State, it cannot afford to give away points, and it would help to develop some form of a ground game. The Black Knights were shut out last week at Stanford. They also boast, at this point, the nation's slowest offense at 31.1 seconds per play, according to data from ESPN Stats & Info.
North Carolina at East Carolina, ESPNU, #UNCvsECU: The Pirates came awfully close to beating a South Carolina team that is probably better than we initially gave it credit for, and they went into Blacksburg, Virginia, last week and took down the Hokies. Now they get the Tar Heels in a rematch of last year's 55-31 ECU rout in Chapel Hill. The Tar Heels have looked underwhelming through two games, and they will be without starting guard Landon Turner. But their offense is still capable of putting plenty of points on the board, and this is a team that certainly has not forgotten about the way it was embarrassed by the Pirates last season. A shootout between Marquise Williams and Shane Carden could be on the horizon. And given UNC's upcoming slate -- at Clemson, Virginia Tech, at Notre Dame -- it better hope it can keep up this time around before league play starts. One thing to keep in mind: With Brian Walker's 100-yard interception return for a touchdown two weeks ago at San Diego State, UNC now has 10 non-offensive touchdowns since last season, according to ESPN Stats & Info. That is tied with North Texas for the second-best mark in the nation during that span, trailing only Florida State's 11.
6 p.m.
Presbyterian at NC State, ESPN3, #PREvsNCSU: The Wolfpack's laughable nonconference slate concludes, and a win here would make them 4-0 after a disappointing 3-9 mark last season. Still, it should do wonders for a young team looking to go bowling in Dave Doeren's second year at the helm, especially if it can replicate its dominant performance from last week at USF. Like its rival in Chapel Hill, NC State needs to do itself a favor, with back-to-back games against FSU and Clemson awaiting in the next two weeks to open conference play. As David Hale notes, quarterback Jacoby Brissett has been invaluable so far for the Pack, leading the ACC in touchdowns and yards and second only to Georgia Tech's Justin Thomas in passer rating.
8 p.m.
Miami at No. 24 Nebraska, ESPN2, #MIAvsNEB: Andrea Adelson and Mitch Sherman did a wonderful job recapping some of the great matchups between these old rivals. What might be the difference at Memorial Stadium, however, is the ground game. Duke Johnson has rushed for at least 90 yards in each of his past five games dating back to last season, while Ameer Abdullah has eclipsed the 100-yard mark in 12 of his past 14 games and has tallied more than 100 yards from scrimmage in 16 straight games, the longest active streak in the nation. The ACC is 6-3 against the Cornhuskers in the past nine meetings, though the Hurricanes are just 1-6 in their past seven games against AP-ranked teams, with an average point margin of minus-22.4.
8 p.m.
No. 22 Clemson at No. 1 Florida State, ABC, #CLEMvsFSU: Here's the matchup we've all been waiting for, but it won't include Jameis Winston. The reigning Heisman Trophy winner will sit out the entire game, the school announced late Friday, after reportedly making profane remarks in public. It will be Sean Maguire's turn to run the show. Maguire has not started a game since Nov. 12, 2011, his senior year at Seton Hall Prep (New Jersey). Coach Jimbo Fisher is 3-1 against Clemson since arriving in Tallahassee, but the lower-ranked team has won two of the past three meetings. The Tigers, meanwhile, are 0-4 all time against AP No. 1 teams, with the last such game coming in the 1999 "Bowden Bowl I" against FSU, a 17-14 Seminoles win. Coming into this contest, ESPN's FPI ranks Clemson 19th, FSU 2nd, and it gives the Seminoles a 77 percent chance to win.